Premium
TENSION OSCILLATION IN ARTERIES AND ITS ABNORMALITY IN HYPERTENSIVE ANIMALS
Author(s) -
Shimamura Keiichi,
Sekiguchi Fumiko,
Sunano Satoru
Publication year - 1999
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.1999.03030.x
Subject(s) - vascular smooth muscle , smooth muscle , contraction (grammar) , intracellular , gap junction , membrane potential , muscle tension , cytoplasm , chemistry , oscillation (cell signaling) , biophysics , population , myocyte , medicine , endocrinology , biology , biochemistry , environmental health , physical medicine and rehabilitation
1. The mechanisms of oscillatory contraction of arterial smooth muscle in vitro are discussed. 2. The membrane potential and cytoplasmic free Ca 2+ concentration in smooth muscle cells oscillate in the presence of agonists. 3. The oscillatory change in the membrane potential of smooth muscle cells is related to Ca 2+ release from intracellular stores. 4. Gap junctions between smooth muscle cells play important roles in the synchronized oscillation of the cytoplasmic free Ca 2+ concentration in this population of cells. 5. Endothelial cells may increase or decrease the tension oscillation of smooth muscle cells. 6. In arteries from hypertensive rats, an increase in membrane excitability and the number of gap junctions between smooth muscle cells and impaired endothelial function are the main factors responsible for the modulation of tension oscillation.