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VERAPAMIL REDUCES INTIMAL HYPERPLASIA IN A SHEEP CAROTID ARTERY PATCH GRAFT MODEL
Author(s) -
Ao Peng Y.,
Hawthorne Wayne J.,
Vicaretti Mauro,
Fletcher John P.
Publication year - 2000
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1046/j.1440-1622.2000.01746.x
Subject(s) - medicine , verapamil , intimal hyperplasia , carotid arteries , artery , hyperplasia , common carotid artery , group a , surgery , urology , gastroenterology , anesthesia , calcium , smooth muscle
Background : The current study investigated the effect of verapamil on the development of intimal hyperplasia (IH) using a sheep model. Methods : A gelatin‐sealed Dacron patch graft was implanted into the left common carotid artery in 40 adult Merino sheep. Sheep were then randomly allocated to four groups. Group 1 were controls given no treatment ( n = 10). Groups 2–4 were treated with intravenous verapamil 0.5 mg/kg per day in two divided doses for different lengths of time. Group 2 ( n = 10) received treatment for 1 week; group 3 ( n = 10) received treatment for 2 weeks and group 4 ( n = 10) received treatment for 4 weeks. All sheep were killed at 4 weeks and the grafted segments of artery were harvested for IH assessment by an image analysis system. Results : The IH index from the three groups treated with verapamil was significantly less than that of the control (group 1, 0.287 ± 0.077; group 2, 0.205 ± 0.064, P < 0.05; group 3, 0.193 ± 0.059, P < 0.01; group 4, 0.171 ± 0.046, P < 0.01). Conclusion : The present study suggests that verapamil inhibits the development of IH even when treatment is given for only 1 week.