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TUMOUR SIZE: THE ONLY PREDICTIVE FACTOR FOR 131 I MIBG UPTAKE IN PHAEOCHROMOCYTOMA AND PARAGANGLIOMA
Author(s) -
Nguyen Hieu H.,
Proye Charles A. G.,
Carnaille Bruno,
Combemale Frederic,
Pattou Francois N.,
Huglo Damien
Publication year - 1999
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1046/j.1440-1622.1999.01570.x
Subject(s) - medicine , paraganglioma , scintigraphy , univariate analysis , pheochromocytoma , nuclear medicine , pathology , predictive value , urology , multivariate analysis
Background : 131 I Meta‐iodobenzylguanidine ( 131 I MIBG) scintigraphy can detect chromaffin tumours with a high specificity but its sensitivity remains limited. In this study, the influence of clinical features and tumour pathology on the results of 131 I MIBG of patients with phaeochromocytomas and paragangliomas was examined. Methods : The records of 104 patients operated on for chromaffin tumours who had pre‐operative 131 I MIBG were reviewed. Demographic data, clinical features, biochemical results and pathology of tumours were analysed. The size of the tumour was assessed by the three measured diameters of the specimen and its calculated volume. Univariate relationship between tumours’ characteristics and the results of 131 I MIBG were examined. Results : Out of 119 tumours, 104 (87%) were detected by 131 I MIBG. Mean ± SD largest diameter and volume of the tumours were 6.0 ± 2.4 cm (range 0.8–11.5 cm) and 68 ± 74 cm 3 (range 0.2–421 cm 3 ). Results of 131 I MIBG were significantly correlated with both the largest diameter of the tumour ( P < 0.01) and by its volume ( P < 0.001). 131 I MIBG was negative in 35.5% of tumours < 20 cm 3 and in 2.6% of those < 20 cm 3 . No other criteria were correlated with positive 131 I MIBG, including aetiology, pathology or catecholamine secretion pattern. Conclusions : The result of 131 I MIBG scanning in patients with chromaffin tumours is significantly correlated with the size of the tumour.