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O'Brien's actinic granuloma in association with prolonged doxycycline phototoxicity
Author(s) -
Lim Davin S,
Triscott Joe
Publication year - 2003
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1046/j.1440-0960.2003.00641.x
Subject(s) - medicine , phototoxicity , dermatology , doxycycline , granuloma annulare , granuloma , papule , miltefosine , sunburn , pathology , giant cell , histiocyte , methoxsalen , lesion , psoriasis , antibiotics , biochemistry , chemistry , leishmaniasis , visceral leishmaniasis , microbiology and biotechnology , in vitro , biology
SUMMARY O'Brien's actinic granuloma is clinically characterized by annular papules and plaques on sun‐exposed areas of skin. These lesions often occur insidiously on a background of severe solar elastosis; however, an acute variant following sunburn has been reported in the literature. We present two cases of acute actinic granuloma precipitated by episodes of sunburn occurring on a background of prolonged doxycycline phototoxicity. Biopsies from both patients showed a histiocytic infiltrate with multinucleate giant cells engulfing elastotic material, with a reduction of elastin towards the centre of the papule. Marked resolution of the lesions was noted after 8 weeks of treatment with betamethasone dipropionate 0.05% ointment in optimized vehicle together with adequate photoprotection in the form of broad‐spectrum sunscreens.