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Staphylococcal scalded skin syndrome complicating acute generalized pustular psoriasis
Author(s) -
Sharkey Michael P,
Muir James B
Publication year - 2002
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1046/j.1440-0960.2002.00595.x
Subject(s) - medicine , staphylococcal scalded skin syndrome , dermatology , pustular psoriasis , psoriasis , generalized pustular psoriasis , staphylococcus aureus , bacteria , biology , genetics
SUMMARY A 60‐year‐old woman with psoriasis vulgaris treated with oral cyclosporin and acitretin developed an acute generalized pustular eruption with erythema and associated fever consistent with acute generalized pustular psoriasis. She was admitted to hospital and, despite intravenous fluid replacement, developed acute renal failure. In addition, she developed staphylococcal septicaemia. After transfer to the intensive care unit because of deteriorating renal function, a sudden onset of widespread flaccid blistering (Nikolsky sign positive) and superficial erosions was noted. Histology of a biopsied blister revealed subcorneal splitting of the epidermis consistent with staphylococcal scalded skin syndrome. The patient was treated with intravenous dicloxacillin and the blistering gradually improved over 10 days.