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Myeloma‐associated systemic amyloidosis presenting with acquired digital cutis laxa‐like changes
Author(s) -
Dicker Tony J,
Morton James,
Williamson Richard M,
Chick Jeff
Publication year - 2002
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1046/j.1440-0960.2002.00579.x
Subject(s) - medicine , cutis laxa , histopathology , plasma cell dyscrasia , dyscrasia , tongue , pathology , amyloidosis , dermatology , macroglossia , skin biopsy , multiple myeloma , biopsy , plasma cell , bone marrow , immunology , antibody , immunoglobulin light chain
SUMMARY A 59‐year‐old woman presented with a 6‐year history of lax skin on the distal fingers of both hands, as well as a recent increase in the size of her tongue. Histopathology of skin from her distal finger showed amyloid deposition and bone marrow biopsy revealed an underlying plasma cell dyscrasia. Initial treatment with cyclophosphamide, vincristine, adriamycin and methylprednisolone has produced a significant reduction in the swelling of both her hands and tongue. Acquired digital cutis laxa‐like changes are a rare cutaneous manifestation of systemic amyloidosis.