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Bullous lesions in Bazex syndrome and successful treatment with oral psoralen phototherapy
Author(s) -
Gill David,
Fergin Peter,
Kelly John
Publication year - 2001
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1046/j.1440-0960.2001.00535.x
Subject(s) - medicine , clearance , psoralen , dermatology , erythema , etretinate , nail (fastener) , basal cell , dyskeratosis , pathology , hyperkeratosis , psoriasis , dna , genetics , materials science , metallurgy , urology , biology
SUMMARY A 59‐year‐old man presented with a psoriasiform dermatitis with associated bullae and destructive nail dystrophy of the hands and feet. He had lost 10 kg weight over 6 months and a mass in the neck was noted. He was provisionally diagnosed with Bazex syndrome (acrokeratosis paraneoplastica) and subsequent investigations revealed a squamous cell carcinoma in the right piriform fossa. His skin lesions were treated with oral psoralen and ultraviolet A phototherapy and this cleared the cutaneous changes, but the nail changes have persisted at 18 months follow up.