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Pemphigus with pemphigoid‐like presentation, associated with squamous cell carcinoma of the tongue
Author(s) -
Wong Kenneth C,
Ho Kenneth K
Publication year - 2000
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1046/j.1440-0960.2000.00434.x
Subject(s) - medicine , acantholysis , pemphigus , bullous pemphigoid , pemphigoid , dermatology , tongue , pathology , basal cell , presentation (obstetrics) , pemphigus vulgaris , paraneoplastic pemphigus , autoantibody , antibody , immunology , surgery
SUMMARY A 53‐year‐old woman presented with an inoperable squamous cell carcinoma of the tongue associated with tense large bullae consistent with bullous pemphigoid, preceded by a prodrome of urticarial plaques. The histological findings showed a regenerating subepidermal blister with eosinophils and no acantholysis. Direct immunofluorescence study, however, showed positive staining for IgG and C3 throughout the epidermis consistent with pemphigus. The blistering eruption had no mucosal involvement and responded to low dose corticosteroids. Our patient may represent another presentation of a ‘paraneoplastic pemphigus spectrum’.