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Pyoderma gangrenosum with secondary pyarthrosis following propylthiouracil
Author(s) -
Darben Troy,
Savige Judy,
Prentice Roger,
Paspaliaris Bill,
Chick Jeffrey
Publication year - 1999
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1046/j.1440-0960.1999.00346.x
Subject(s) - pyoderma gangrenosum , medicine , propylthiouracil , rheumatoid arthritis , anti neutrophil cytoplasmic antibody , inflammatory bowel disease , synovitis , dermatology , spondyloarthropathy , immunology , vasculitis , pathology , disease , thyroid
The association of pyoderma gangrenosum and arthritic symptoms is well documented. We present a rarely reported variant of this in a 44‐year‐old woman with pyoderma gangrenosum and bilateral large purulent effusions of her knees. She had no evidence of underlying rheumatoid arthritis or a specific seronegative spondyloarthropathy. Of note she had a history of Graves’ disease for which she had been treated with propylthiouracil for 3 years and on investigation at this presentation had a markedly elevated perinuclear antineutrophil cytoplasm antibody (P‐ANCA) level with specificities for IgM myeloperoxidase, IgG elastase and IgG lactoferrin. We believe this patient had pyoderma gangrenosum with secondary sterile pyarthrosis and a P‐ANCA precipitated by propylthiouracil.