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Postovulatory Effect of Intravenous Administration of Lipopolysaccharide ( Escherichia coli , O55:B5) on the Endocrine Status of Recently Ovulated Sows
Author(s) -
Mwanza AM,
Madej A,
Kindahl H,
Lundeheim N,
Einarsson S
Publication year - 2001
Publication title -
reproduction in domestic animals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.546
H-Index - 66
eISSN - 1439-0531
pISSN - 0936-6768
DOI - 10.1046/j.1439-0531.2001.00279.x
Subject(s) - lipopolysaccharide , estrous cycle , metabolite , prostaglandin , endocrinology , medicine , ovulation , hormone , endocrine system , weaning , saline , endometritis , biology , pregnancy , genetics
The effects of lipopolysaccharide ( Escherichia coli , O55:B5), administered 18 h after ovulation in the second oestrus after weaning on the hormonal profiles in 14 Swedish cross‐bred (Landrace × Yorkshire) multiparous sows were studied. The endotoxin group (E‐group) sows were administered with 300 ng/kg of lipopolysaccharide (LPS) whereas the control group (C‐group) sows were administered 5 ml of saline intravenously via an indwelling jugular cannula. Blood samples for hormonal analyses were collected from all sows until slaughter. In the E‐group, progesterone, cortisol and prostaglandin F 2α metabolite levels increased significantly (p < 0.05) following LPS compared with the C‐group. It can be concluded from this study that apart from elevating cortisol and prostaglandin F 2α metabolite, LPS also elevates progesterone levels.