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Cryptococcus ‐Meningitis bei kindlichem systemischem Lupus erythematodes
Author(s) -
Liou J.,
Chiu C.,
Tseng C.,
Chi C.,
Fu L.
Publication year - 2003
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1046/j.1439-0507.2003.00861.x
Subject(s) - medicine , fluconazole , vomiting , meningitis , amphotericin b deoxycholate , amphotericin b , cryptococcus neoformans , cryptococcosis , latex fixation test , prednisolone , complication , mycosis , cerebrospinal fluid , gastroenterology , dermatology , surgery , immunology , antifungal , antibody , biology , caspofungin , genetics
Summary Cryptococcal meningitis is an uncommon but often fatal complication of systemic lupus erythematosus (SLE). We report on a 13‐year‐old girl with SLE using high‐dose prednisolone for several months, presented to us with low grade fever, intermittent vomiting and headache. Physical examination, including papilloedema and meningeal irritation, was unremarkable. Serum and cerebrospinal fluid (CSF) cryptococcal antigen titer was 1 : 128 by latex agglutination method. CSF culture yielded Cryptococcus neoformans . We used amphotericin B deoxycholate (a cumulative dose of 1.95 gm) and fluconazole (200 mg day −1 ) for 6 weeks. Clinical response was good. Then, we continued fluconazole 200 mg per qd as suppressive therapy for thirty‐four months. There were no neurological sequelae or relapse after 20‐month follow‐up. Timely diagnosis and effective antifungal therapy could improve the prognosis of cryptococcal meningitis in SLE patients.