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Paecilomyces variotii central nervous system infection in a patient with cancer
Author(s) -
Kantarcıoğlu A. S.,
Hatemi G.,
Yücel A.,
De Hoog G. S.,
Mandel N. M.
Publication year - 2003
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1046/j.1439-0507.2003.00837.x
Subject(s) - miconazole , paecilomyces , flucytosine , itraconazole , fluconazole , amphotericin b , microbiology and biotechnology , cancer , cerebrospinal fluid , antifungal , medicine , biology , pathology , botany
Summary Paecilomyces variotii was isolated from two subsequent cerebrospinal fluid (CSF) specimens of a cancer patient. Identification was confirmed through β ‐tubulin and rDNA ITS sequencing. MICs were determined for seven antifungal agents; the isolate was found to be susceptible to amphotericin B (AMB), itraconazole (ITZ), ketaconazole (KTZ) and 5‐fluorocytosine (5FC) but resistant to fluconazole (FLZ) and miconazole (MCZ). Despite antimycotic therapy, the infection proved to be fatal.