Premium
Antifungal effect of Hevea brasiliensis latex with various fungi. Its synergistic action with amphotericin B against Candida albicans
Author(s) -
Giordani R.,
Regli P.,
Buc J.
Publication year - 2002
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1046/j.1439-0507.2002.00809.x
Subject(s) - cryptococcus neoformans , hevea brasiliensis , microbiology and biotechnology , candida albicans , amphotericin b , biology , antifungal , fungi imperfecti , corpus albicans , chemistry , natural rubber , organic chemistry
Summary. Antifungal activity of latex from Hevea brasiliensis was observed with various fungi in macrobroth dilution assays. The strongest antifungal effect was obtained with Trichosporon cutaneum (MIC 80%=40.615 μ g protein ml −1 , K aff =0.075 μ g −1 protein ml) and Cryptococcus neoformans (MIC 80%=56.078 μ g protein ml −1 , K aff =0.059 μ g −1 protein ml). Amphotericin B was synergized with all H. brasiliensis latex concentrations tested. The rates of synergy were about 50, 44 and 55% with 15, 30 and 60 μ g protein ml −1 latex, respectively. The putative role of glycosidase activities measured in crude latex, especially α‐ d ‐mannosidase and N ‐acetyl‐β‐ d ‐glucosaminidase activities which are potentially able to split off intraparietal linkages between glycosidic residues, is discussed. The possible role of another antifungal factor associated with rubber particles of latex is suggested.