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In vitro susceptibilities of 11 clinical isolates of Exophiala species to six antifungal drugs
Author(s) -
Meletiadis J.,
Meis J. F. G. M.,
De Hoog G. S.,
Verweij P. E.
Publication year - 2000
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1046/j.1439-0507.2000.00585.x
Subject(s) - antifungal , in vitro , microbiology and biotechnology , antifungal drugs , biology , medicine , biochemistry
Summary The antifungal activities of miconazole, terbinafine, itraconazole, UR 9825, voriconazole and amphotericin B against 11 clinical isolates of Exophiala spp. were tested by the broth microdilution method. All drugs were very active against Exophiala spp.. The 90% minimal inhibitory concentration (MIC 90 ) ranged from 0.125 to 1 μg ml −1 . Terbinafine was the most active drug against Exophiala spinifera , Exophiala dermatitidis and Exophiala castellanii and seems to be a promising agent in the treatment of infections caused by these fungi.