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Itraconazole lung concentrations in haematological patients
Author(s) -
Coronel B.,
Levron J. C.,
Van Devenne D. Dorez A.,
Archimbaud E.,
Mercatello A.
Publication year - 2000
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1046/j.1439-0507.2000.00565.x
Subject(s) - itraconazole , medicine , lung , intensive care medicine , dermatology , antifungal
Itraconazole distribution is largely dependent on its high liposolubility. Intrapulmonary lung concentrations remain unknown in haematological patients. We report itraconazole lung concentrations in such patients treated with itraconazole. Itraconazole and hydroxy‐itraconazole were measured by high‐performance liquid chromatography in concomitant blood samples and lung post‐mortem biopsies (three cases) or lung lobectomy (one case). These itraconazole and metabolite lung concentrations were sufficient to be active on Aspergillus .