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Alterations in spore production in Trichophyton rubrum treated in vitro with 1‐amino‐6‐methyl‐4‐phenylpyrazolo[3,4‐ d ]‐1,2,3‐triazole
Author(s) -
Mares Donatella,
Romagnoli C.,
Sacchetti G.,
Vicentini C. B.,
Bruni A.
Publication year - 1999
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1046/j.1439-0507.1999.00490.x
Subject(s) - trichophyton rubrum , in vitro , microbiology and biotechnology , chemistry , biology , biochemistry , antifungal
The effects of the newly synthesized triazole, 1‐amino‐6‐methyl‐4‐phenylpyrazolo[3,4‐ d ]‐1,2,3‐triazole (V5), on the dermatophyte Trichophyton rubrum were tested. Optical and electron microscopy showed that the treatment suppressed the various forms of saprophytic conidia, induced the formation of chlamydospores and accelerated the formation of arthroconidia. This new triazole did not reveal any fungistatic or fungicidal activity and could not be considered as an antifungal substance.