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Immunostimulating effect of triiodothyronine: dietary administration of triiodothyronine in rohu ( Labeo rohita ) enhances immunity and resistance to Aeromonas hydrophila infection
Author(s) -
Sahoo P. K.
Publication year - 2003
Publication title -
journal of applied ichthyology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.392
H-Index - 62
eISSN - 1439-0426
pISSN - 0175-8659
DOI - 10.1046/j.1439-0426.2003.00349.x
Subject(s) - aeromonas hydrophila , labeo , biology , triiodothyronine , globulin , titer , immunity , albumin , immunostimulant , carp , zoology , immune system , medicine , endocrinology , antibody , immunology , fishery , fish <actinopterygii> , thyroid
Summary The immunomodulatory effects of dietary administration of 3,3 ′ ,5‐triiodo‐ l ‐thyronine (T 3 ) at 0, 1, 5 and 10 mg kg −1 of diet for 60 days in rohu ( Labeo rohita ) fingerlings were studied. Oral administration of T 3 at all dose levels resulted in significantly (P<0.05) higher serum T 3 levels, total serum protein and globulin levels, and reduced albumin–globulin ratio (A : G) compared with the control group, whereas feeding of T 3 at 5 and 10 mg kg −1 diet enhanced the growth and superoxide production by neutrophils. At the end of the 60‐day experimental period the optimum dosage of T 3 appeared to be the 5 mg kg −1 diet for rohu fingerlings, resulting in a significantly higher specific antibody titre against formalin‐killed Aeromonas hydrophila and lowering the mortality percentage against the A. hydrophila challenge.