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Serum ascorbic acid concentrations in previously unsupplemented greyhounds after administration of a single dose of ascorbic acid intravenously or per os
Author(s) -
Scott K. C.,
Hill R. C.,
Lewis D. D.,
Gronwall R.,
Sundstrom D. A.,
Jones G. L.,
Harper J.
Publication year - 2002
Publication title -
journal of animal physiology and animal nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.651
H-Index - 56
eISSN - 1439-0396
pISSN - 0931-2439
DOI - 10.1046/j.1439-0396.2002.00378.x
Subject(s) - ascorbic acid , vitamin c , vitamin , medicine , plasma concentration , oral administration , oral dose , endocrinology , zoology , chemistry , food science , biology
Summary Plasma vitamin C concentrations (mean + SD) were measured after a large (1 g) dose of vitamin C was administered orally or intravenously to each of four trained greyhounds in a randomized cross‐over design. Concentrations increased (p<0.05) for 2 h but returned to baseline by 6 h after supplementation. Peak concentrations were greater (p<0.01) after intravenous than oral administration (6.1±1.2 vs. 0.54±0.23 mg/dl). This suggests that vitamin C must be administered many times daily to maintain plasma concentrations above normal.