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Influence of dietary phosphorus deficiency with or without addition of fumaric acid to a diet in pigs on bone parameters
Author(s) -
LIESEGANG A.,
URSPRUNG R.,
GASSER J.,
SASSI M.L.,
RISTELI J.,
RIOND J.L.,
WANNER M.
Publication year - 2002
Publication title -
journal of animal physiology and animal nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.651
H-Index - 56
eISSN - 1439-0396
pISSN - 0931-2439
DOI - 10.1046/j.1439-0396.2002.00355.x
Subject(s) - fumaric acid , n terminal telopeptide , bone resorption , osteocalcin , phosphorus , medicine , endocrinology , alkaline phosphatase , chemistry , acid phosphatase , bone mineral , bone remodeling , phosphorus deficiency , zoology , biochemistry , biology , osteoporosis , enzyme , organic chemistry
The purpose of this study was to examine if substantial bone loss occurs in weaned pigs by feeding a phosphorus‐deficient diet with or without fumaric acid. Eighteen weaned pigs were used. The animals were assigned to three groups: group C (control; 0.65% P on DM basis), group LP (low phosphorus; 0.37% P on DM basis) and group LPF (low phosphorus plus fumaric acid; 0.35% P on DM basis plus 2% fumaric acid). These three diets were fed to the groups for a period of four weeks after a two‐week adaptation period. Blood samples were collected once a week. Carboxyterminal telopeptide of type I collagen (ICTP) in serum was used as a bone resorption marker. Osteocalcin (OC) and bone‐specific alkaline phosphatase (bAP) were used as bone formation markers. Bone mineral density (BMD) and content (BMC) were determined by peripheral quantitative computer tomography. BAP activities significantly increased (24%) in group LPF, and at the last sampling day group LPF had significantly increased activities in comparison to group C. In contrast, ICTP concentrations significantly increased with time in group LP and LPF, and at the last sampling day group LPF had significantly increased activities in comparison to group C. BMD and BMC in femur and tibia significantly decreased in group LP and LPF. The results show that P‐deficient diets induce a bone loss. Fumaric acid did not influence the degree of bone loss. With a better understanding of its effect on bone, dietary phosphorus requirements in pigs could be more precisely defined.