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Studies on energy metabolism in lines of mice selected for different growth parameters
Author(s) -
Klein M.,
Schadereit R.,
Scholze H.,
Renne U.
Publication year - 1999
Publication title -
journal of animal physiology and animal nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.651
H-Index - 56
eISSN - 1439-0396
pISSN - 0931-2439
DOI - 10.1046/j.1439-0396.1999.812197.x
Subject(s) - body weight , zoology , biology , selection (genetic algorithm) , growth rate , control line , energy metabolism , weight gain , biochemistry , endocrinology , mathematics , geometry , transmission line , engineering , artificial intelligence , computer science , electrical engineering
Growth is a very complex physiological process and is controlled by many genes and therefore easy to manipulate by selective breeding. Such manipulation of growth was realized by long‐term selection of laboratory mice for different growth parameters (body weight, total protein amount in the carcass and an index combining body weight and endurance fitness) resulting in a high phenotypic and genetic differentiation compared to the nonselected control (Bünger et al. 1983, 1992, 1994; Renne et al. 1995). After 70 generations the 42‐day body weights increased from 28 g at the start of selection to 58.3 g, 51.9 g and 47.4 g in these lines, respectively (Bünger et al. 1994). At the same time the carcass protein content increased from 2.92 to 5.23 g in the line selected for protein mass without an increase of fat percentage up to the age of 42 days (Renne et al. 1995). In comparison with that, selection for body weight was accompanied by a marked increase of fat percentage up to this age as reported in literature for many long‐term selection experiments. Because of the different chemical composition of the body gain at relatively small differences in growth rate, these selected lines seemed to be suitable models for studying some aspects of energetic efficiency of growth. The results of a former experiment conducted in generations 32–42 suggested a higher efficiency of energy utilization in the line selected for body weight than in the other selected lines (Bünger et al. 1987). The objective of the present study was to characterize the energy metabolism of these different selected lines complementary to the studies on protein metabolism given by Schadereit et al. (1997, 1998).