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Homeostatic adjustments of iodine metabolism and tissue iodine to widely varying iodine supply in 125I labeled rats
Author(s) -
Kirchgessner By M.,
He J.,
Windisch W.
Publication year - 1999
Publication title -
journal of animal physiology and animal nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.651
H-Index - 56
eISSN - 1439-0396
pISSN - 0931-2439
DOI - 10.1046/j.1439-0396.1999.00232.x
Subject(s) - homeostasis , iodine , excretion , chemistry , trace element , organism , biology , environmental chemistry , biochemistry , endocrinology , paleontology , organic chemistry
Introduction The homeostatic regulation of nutrient flow through the body is a fundamental ability of living organisms and has been shown to be active also in the case of several trace elements (K irchgessner 1993; K irchgessner et al. 1997). The basic function of homeostasis is to maintain the body’s internal status of the trace elements within physiologically tolerable margins by controlling at least one of the major trace element fluxes: the true absorption of the trace elements from the diet into the body, the reflux from the body into the faeces (endogenous faecal excretion), and the urinary excretion. Furthermore iodine may be a candidate to homeostatic regulation since dietary iodine contents may vary over a wide range and it may be important to the organism to maintain a constant internal status also of this essential trace element. However, quantitative iodine balance measurements are hardly available from the literature and thus knowledge about the existence of iodine homeostasis and its mode of action is still fragmentary. An additional problem also was the lack of appropriate methods to quantify true absorption and endogenous faecal excretion of iodine. However, a recent study has overcome this methodological barrier by adapting the isotope‐dilution technique to iodine (W indisch et al. 1999). Therefore, the aim of the present experiment was to quantify possible homeostatic adaptations of iodine metabolism to dietary iodine ranging from deficient to excessive supplies and to measure the interactions to tissue iodine.