Premium
Associations between the c‐myc proto‐oncogene and carcass quality traits in the pig: evidence for epistasis with the Ryr1 ‐gene
Author(s) -
Reiner By G.,
Moser G.,
Geldermann H.,
Dzapo V.
Publication year - 1999
Publication title -
journal of animal breeding and genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.689
H-Index - 51
eISSN - 1439-0388
pISSN - 0931-2668
DOI - 10.1046/j.1439-0388.1999.00200.x
Subject(s) - biology , genotype , gene , epistasis , genetics , intramuscular fat , single nucleotide polymorphism , zoology
The nucleotide sequence data referred to in this paper have been submitted to GenBank and have been assigned the accession number X97040 . c‐myc is an ubiquitous nuclear phosphoprotein involved in the regulation of cell‐growth, differentiation and apoptosis. Higher nuclear levels of c‐myc block adipogenesis and trigger the onset of myogenesis and folliculogenesis. The c‐myc proto‐oncogene has the potential of a mediator between second messengers such as calcium and cAMP and gene expression. As both are involved in stress‐susceptibility and carcass quality in the pig, this study investigates associations between c‐myc genotypes and carcass quality traits as well as interactions with the Ryr1 genotype in this species. An association between c‐myc and carcass fat traits was evident, but did not reach genome‐wide significance levels. Significance niveaus, explained variance and mean differences between the homozygotes of the Ryr1 ‐gene which clearly decreased from the AA‐genotype to the BB‐genotype of c‐myc are indicating a gene interaction between both genes. Mean differences in lean percentage (expressed in SD) decreased by 89.2% in ME × PI and by 86.3% in WS × PI. The existing but weakly developed significances of the association between c‐myc and carcass fat traits are discussed under the aspect of epistatic nullification.