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Fallberichte
Author(s) -
Eva Giesecke,
Alexander Enk,
Kerstin Steinbrink
Publication year - 2004
Publication title -
jddg: journal der deutschen dermatologischen gesellschaft
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 60
eISSN - 1610-0387
pISSN - 1610-0379
DOI - 10.1046/j.1439-0353.2004.04761.x
Subject(s) - medicine , citation , library science , computer science
High-dose immunoglobulins (IVIG) are important agents in the treatment of numerous autoimmune disorders. In the field of dermatology, increasing numbers of patients with bullous autoimmune disorders and mixed connective tissue diseases have been treated. We successfully treated a patient with pemphigus vulgaris with IVIG, after he had developed osteonecrosis of his right femoral head while on azathioprine and corticosteroids. After reduction of oral corticosteroids, his disease flared dramatically. The addition of a high dose immunosuppressive regimen including azathioprine and dapsone failed to help. Thus high dose IVIG (2 mg/kg, 4 weeks interval) therapy was initiated and induced complete healing of the skin lesions. The clinical improvement and the titer of the relevant autoantibodies against desmoglein 3 and desmoglein 1 showed correlation.