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Embryo development, pregnancy and twin delivery after microinjection of ‘stump’ spermatozoa
Author(s) -
Favero R.,
Rizzo F.,
Baccetti B.,
Piomboni P.
Publication year - 1999
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1046/j.1439-0272.1999.00288.x
Subject(s) - intracytoplasmic sperm injection , microinjection , andrology , sperm , human fertilization , embryo , biology , offspring , male infertility , embryo transfer , oocyte , pregnancy , infertility , reproduction , semen , gynecology , genetics , medicine , endocrinology
Intracytoplasmic sperm injection was performed with immotile spermatozoa affected by tail ‘stump’ defect, and resulted in normal fertilization, embryo transfer and pregnancy in a 35‐year‐old female. The husband had a consanguineous ancestry. Two healthy babies, a male and a female, were born and this confirms that male infertility due to certain genetic sperm defects can be overcome by the intracytoplasmic sperm injection‐assisted reproduction technique. The likely genetic origin of this sperm defect and the probability of the male offspring inheriting this sperm defect should be considered. The fertilization ability of stump spermatozoa, microinjected into the oocyte, is explained on the basis of experience from our previous research.