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Neurotrophin 3 and its Receptor TrkC Immunoreactivity in Glucagon Cells of Buffalo Pancreas
Author(s) -
Lucini C.,
Costagliola C.,
Borzacchiello G.,
Castaldo L.
Publication year - 2003
Publication title -
anatomia, histologia, embryologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.34
H-Index - 35
eISSN - 1439-0264
pISSN - 0340-2096
DOI - 10.1046/j.1439-0264.2003.00467.x
Subject(s) - tropomyosin receptor kinase c , neurotrophin 3 , neurotrophin , biology , enteroendocrine cell , autocrine signalling , endocrinology , pancreas , medicine , low affinity nerve growth factor receptor , glucagon , receptor tyrosine kinase , immunohistochemistry , receptor , endocrine system , microbiology and biotechnology , kinase , platelet derived growth factor receptor , immunology , biochemistry , growth factor , insulin , hormone , neurotrophic factors , brain derived neurotrophic factor
Summary Neurotrophin 3 (NT3), a member of the neurotrophin family, and its specific receptor tyrosine kinase C (TrkC) are involved in the differentiation, survival, and maintenance of many neuronal populations. Recently, NT3 and TrkC were also retained involved in the biology of non‐neuronal tissues. In this study, we report the presence of NT3‐ and TrkC‐immunoreactive cells in the endocrine pancreas of adult buffalos. They were usually distributed at the periphery of islets and showed intense immunoreactivity. By double immunohistochemical staining, NT3‐ and TrkC‐IR resulted to be colocalized in glucagon immunoreactive cells. These findings suggest endocrine and/or autocrine roles of NT3 in pancreatic A cells.