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Distribution of Nociceptin‐like Immunoreactivity in the Central Nervous System of the Mongolian Gerbil: an Immunohistochemical Study
Author(s) -
KIM H. W.,
Kwon Y. B.,
Ham T. W.,
Roh D. H.,
Yoon S. Y.,
Han H. J.,
Kim K. W.,
Lee W. S.,
Kim J. K.,
Yoon O. B.,
Lee J. H.
Publication year - 2002
Publication title -
anatomia, histologia, embryologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.34
H-Index - 35
eISSN - 1439-0264
pISSN - 0340-2096
DOI - 10.1046/j.1439-0264.2002.00389.x
Subject(s) - nociceptin receptor , central nervous system , locus coeruleus , periaqueductal gray , colchicine , medicine , chemistry , neuroscience , endocrinology , anatomy , receptor , biology , opioid peptide , midbrain , opioid
Summary This study is designed to demonstrate the distribution of nociceptin, endogenous ORL1 receptor ligand, in the central nervous system of the Mongolian gerbil. To intensify the nociceptin‐like immunoreactivity (NOC‐LI), colchicine was administered into the lateral ventricle, at 48 h prior to the trans‐cardiac perfusion. In the group without colchicine treatment, NOC‐LI was observed in the fibres of the spinal dorsal horn, specifically in the superficial layers. However, the NOC‐LI in the superficial layers disappeared after the administration of colchicine. In the brain, NOC‐LI was prominent in the hypothalamus, hippocampus, cerebral peduncle, substantia nigra, dorsal raphe, periaqueductal grey, locus coeruleus and trapezoid nucleus. Colchicine treatment markedly intensified the NOC‐LI in the somata of the central nervous system, whereas the untreated sections were too weak to observe and analyse. The distribution of NOC‐LI provides informative data for studies of the neuronal circuit that nociceptin may be involved in.