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Involution of Bursa Cloacalis (Fabricii) and Thymus in Cyclosporin A‐Treated Chickens
Author(s) -
MILIĆEVIĆ Ž.,
ŽIVANOVIĆ V.,
MILIĆEVIĆ N. M.
Publication year - 2002
Publication title -
anatomia, histologia, embryologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.34
H-Index - 35
eISSN - 1439-0264
pISSN - 0340-2096
DOI - 10.1046/j.1439-0264.2002.00358.x
Subject(s) - involution (esoterism) , epithelium , basement membrane , biology , medulla , follicle , medicine , endocrinology , anatomy , pathology , consciousness , genetics , neuroscience
Fifty‐day‐old Arbor Acres chickens received a daily oral dose of 30 mg/kg Cyclosporin A for 21 consecutive days. This treatment induced the striking morphological changes in the bursa cloacalis (Fabricii). The number of bursal follicles did not change, but they were markedly decreased in size. The pars lymphoreticularis was collapsed and contained smaller accumulations of lymphocytes. The pars lymphoepithelialis was almost totally devoid of lymphocytes and it was composed of an empty network of epithelial cells. Interfollicular epithelium, follicle‐associated epithelium, basement‐membrane‐associated epithelium and bursal epithelial cytoreticulum were not changed. The thymus also displayed substantial structural changes, whereby the thymic medulla was strongly reduced in size.