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Effects of Dimecron on Developing Chick Embryo: Malformations and other Histopathological Changes
Author(s) -
SAHU C. R.,
GHATAK S.
Publication year - 2002
Publication title -
anatomia, histologia, embryologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.34
H-Index - 35
eISSN - 1439-0264
pISSN - 0340-2096
DOI - 10.1046/j.1439-0264.2002.00355.x
Subject(s) - embryo , organogenesis , biology , yolk , yolk sac , embryogenesis , andrology , incubation , growth retardation , teratology , physiology , pregnancy , fetus , medicine , microbiology and biotechnology , genetics , food science , biochemistry , gene
The effect of dimecron, an organophosphorus insecticide, on developmental alterations and histopathological damage was determined in the developing chick embryo. The insecticide was administered at two different doses (25 μg and 35 μg) into the egg yolk through a pore into the equatorial region at day 0 of incubation. Significant abnormalities in relation to organogenesis and overall retardation in growth were noted in the insecticide‐treated embryos. Histopathological study of the treated whole embryo showed abnormal features in the formation of different vital organs. The liver and kidney were severely affected by the pesticide at both doses. Based upon these findings it may be concluded that dimecron does play a role in producing embryotoxicity at different stages of embryogenesis.