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Identification of Positive Cells to Interleukin‐4 in Bovine Haemal Nodes
Author(s) -
Cerutti P.,
Guerrero F.
Publication year - 2001
Publication title -
anatomia, histologia, embryologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.34
H-Index - 35
eISSN - 1439-0264
pISSN - 0340-2096
DOI - 10.1046/j.1439-0264.2001.00320.x
Subject(s) - biology , immune system , lymphatic system , immunology , lymphocyte , t lymphocyte , parenchyma , antibody , interleukin 2 , botany
The bovine haemal nodes are lymphatic organs located in the haemal circulation. Their parenchyma is represented by plasma cells, macrophages and B and T lymphocytes. The T helper type 2 (Th2) CD4 lymphocyte can be found within the T lymphocytes. The activated Th2 CD4 lymphocyte produces interleukin‐4 (IL‐4), a peptidic hormone involved in the acute‐phase immune response. This interleukin can promote either B‐lymphocyte differentiation and T‐lymphocyte proliferation or it can promote the type of immunoglobulin that can be liberated. Our results have shown, by immunostaining with anti‐IL‐4, not only the presence and localization of these lymphocytes in bovine haemal nodes but also the participation of polymorphonuclear cells (neutrophils) in the storage of IL‐4. These results give value to the humoral and cellular immunological importance of haemal nodes in bovines and they can serve as a contribution to determine the cross‐reactivity of bovine IL‐4 with the human anti‐serum used in this work.