Premium
Minireview
Author(s) -
Factors Growth,
System Their Receptors in the Olfactory
Publication year - 1999
Publication title -
anatomia, histologia, embryologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.34
H-Index - 35
eISSN - 1439-0264
pISSN - 0340-2096
DOI - 10.1046/j.1439-0264.1999.00165.x
Subject(s) - neurogenesis , biology , fibroblast growth factor , neuroscience , neurite , olfactory bulb , olfactory epithelium , nerve growth factor , amphiregulin , epidermal growth factor , sensory system , receptor , microbiology and biotechnology , central nervous system , biochemistry , in vitro
Received July, 1998; accepted for publication July, 1998 The olfactory epithelium is unique in the mammalian nervous system as it is a site of continual neurogenesis. Constant turnover of primary sensory neurons in the periphery results in continuous remodeling of neuronal circuits and synapses in the olfactory bulb throughout life. Most of the specific mechanisms and factors that control and modulate this process are not known. Recent studies suggest that growth factors, and their receptors, may play a crucial role in the development and continuous regeneration of olfactory neurons, i.e. particularly in neuronal proliferation, neurite outgrowth, fasciculation and synapse formation of the olfactory system. The potential role of the following factors and their receptors in different species are reviewed: Nerve growth factor (NGF); insulin‐like growth factors (IGFs); fibroblast growth factors (FGFs); epidermal growth factor (EGF); transforming growth factor α (TGF α); amphiregulin (AR) and transforming growth factors β (TGFs β).