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The Coexistence of Calcitonin Gene‐Related Peptide and Substance P in Pericellular Arborization and Satellite Cell of Goat Trigeminal and Nodose Ganglia
Author(s) -
Kang T. C.,
Seo J.,
Song S. H.,
Kim Y. W.,
Yi S. J.,
Kim J. S.,
Won M. H.,
Lee I. S.,
Lee H. S.
Publication year - 1999
Publication title -
anatomia, histologia, embryologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.34
H-Index - 35
eISSN - 1439-0264
pISSN - 0340-2096
DOI - 10.1046/j.1439-0264.1999.00160.x
Subject(s) - calcitonin gene related peptide , nodose ganglion , calcitonin , substance p , colocalization , immunohistochemistry , biology , trigeminal ganglion , sensory system , anatomy , pathology , chemistry , neuroscience , neuropeptide , endocrinology , medicine , receptor , immunology , vagus nerve , biochemistry , stimulation
Pericellular arborization is reported to be the self‐regulating structure in sensory ganglia. Although the calcitonin gene‐related peptide (CGRP) or substance P (SP) immunoreactive pericellular arborization appeared in the sensory ganglia, there was no available information that CGRP and SP colocalize in this structure. As the attempts to resolve the question described above, the present study was undertaken to identify the coexistence of CGRP and SP in pericellular arborizations of the goat nodose and trigeminal ganglia by double immunohistochemistry. As the results show, CGRP immunoreactivity was present in every pericellular arborization containing SP immunoreactivity in trigeminal ganglia, however, pericellular network containing CGRP or SP immunoreactivity was not present in nodose ganglia. Unexpectedly, a few small satellite elements were observed to contain intense CGRP and SP immunoreactivity at the periphery of CGRP and SP immunoreactive neurones in nodose ganglia. Therefore, these results suggest that CGRP and SP coexsit in pericellular arborizations, and that satellite cell as well as pericellular arborization may be involved in intraganglionic regulation of goat sensory ganglia.