Open AccessMicrotubule motors in spindle and chromosome motility
Author(s) -
Endow Sharyn A.
Publication year - 1999
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1046/j.1432-1327.1999.00339.x
Subject(s) - dynein , chromosome segregation , kinesin , microbiology and biotechnology , spindle pole body , microtubule , mitosis , biology , spindle apparatus , kinetochore , motor protein , meiosis , motility , chromosome , cell division , genetics , cell , gene
Many of the kinesin microtubule motor proteins discovered during the past 8–9 years have roles in spindle assembly and function or chromosome movement during meiosis or mitosis. The discovery of kinesin motor proteins with a clear involvement in spindle and chromosome motility, together with recent evidence that cytoplasmic dynein plays a role in chromosome distribution, has attracted great interest. The identification of microtubule motors that function in chromosome distribution represents a major advance in understanding the forces that underlie chromosome and spindle movements during cell division.