Open AccessStructural and energetic determinants of the S 1 ‐site specificity in serine proteases
Author(s) -
Czapinska Honorata,
Otlewski Jacek
Publication year - 1999
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1046/j.1432-1327.1999.00160.x
Subject(s) - proteases , serine , substrate specificity , enzyme , biology , computational biology , biochemistry , chemistry
In recent years the number of determined three‐dimensional structures of serine proteases that are accompanied by detailed mutational studies has grown rapidly. In particular, spatial structures have been described for enzymes involved in processes of critical medical significance, often related to severe pathophysiological diseases. There has also been significant progress in the understanding of the structural grounds for the substrate specificity of serine proteases. This review is concerned mainly with primary structural determinants of the S 1 specificity, the crucial component of substrate selectivity, often in relation to more distant specificity elements, which cooperatively influence the S 1 site.