Open AccessStructure of the human β 2 ‐glycoprotein I (apolipoprotein H) gene*
Author(s) -
Okkels Henrik,
Rasmussen Thomas E.,
Sanghera Dharambir K.,
Kamboh M. Ilyas,
Kristensen Torsten
Publication year - 1999
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1046/j.1432-1327.1999.00063.x
Subject(s) - glycoprotein , apolipoprotein b , gene , apolipoprotein c2 , genetics , microbiology and biotechnology , biology , biochemistry , lipoprotein , cholesterol , very low density lipoprotein
The gene encoding the human plasma protein β 2 ‐glycoprotein I or apolipoprotein H was cloned and its structure determined. The gene which consists of eight exons was shown to span 18 kb and was localized to chromosome 17q23‐24. The transcriptional initiation site was assigned to a position 31 bp upstream of the start codon. Several consensus sequence elements relevant for regulation of transcription in liver were seen in the 5′‐upstream region of the gene. Exon 1 contains the 5′‐UTR together with the signal peptide coding sequences. Short consensus repeats (SCRs) 1, 3, 4, and 5 are encoded by single exons each while SCR2 is encoded by two exons. Exon 8 comprises the region encoding the C‐terminal end of β 2 ‐glycoprotein I (from His‐310), the stop codon and the 3′‐UTR.