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Quality assessment of seven types of fresh‐frozen plasma leucoreduced by specific plasma filtration
Author(s) -
Chabanel A.,
Sensebé I.,
Masse M.,
Maurel J. P.,
Plante J.,
Hivet D.,
Kannengiesser C.,
Naegelen C.,
Joussemet M.,
Marchesseau B.,
Rasongles P.,
Proust F.,
David C.,
Montembault A. M.,
Bergeat P.
Publication year - 2003
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1046/j.1423-0410.2003.00288.x
Subject(s) - filtration (mathematics) , chemistry , chromatography , coagulation , blood plasma , size exclusion chromatography , plasma , fresh frozen plasma , andrology , immunology , platelet , medicine , biochemistry , enzyme , statistics , physics , mathematics , quantum mechanics
Background and Objectives A study was undertaken to determine plasma quality after specific filtration. Materials and Methods Seven types of plasma were tested, after filtration of plasma from filtered or non‐filtered whole blood. Leucocyte counting was carried out after a 30‐fold concentration of the sample. Twenty‐nine parameters (including coagulation testing, proteins, coagulation factors and activation markers) were measured before and after filtration, and after 6 months of storage. Results After specific plasma filtration, the average residual leucocyte counts were less than 2250/l. In spite of small statistically significant changes in proteins, coagulation factors and complement activation, this study showed that plasma filtration did not alter plasma quality. After 6 months of storage at −30 °C, factor VIII recovery varied between 91 and 109%. Haemostasis parameters and activation markers remained within the normal range. Conclusions Specific plasma filtration reduced the leucocyte number to < 10 4 leucocytes/l. The quality of plasma was not altered by the additional step of specific plasma filtration.