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Transfusion‐associated graft‐versus‐host disease in a patient with Waldenstrom's macroglobulinaemia
Author(s) -
Munro L. R.,
Culligan D. J.,
Grant A.,
Johnston P. W.,
Watson H. G.
Publication year - 2002
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1046/j.1423-0410.2002.00202.x
Subject(s) - medicine , lymphoma , immunology , human leukocyte antigen , disease , graft versus host disease , blood transfusion , gastroenterology , antigen
Background and Objectives Routine irradiation of cellular blood products is not presently recommended for patients with non‐Hodgkin's lymphoma (NHL). Materials and Methods We report the case of a 72‐year‐old‐man with Waldenstrom's macroglobulinaemia who developed transfusion‐associated graft‐versus‐host disease (TA‐GvHD) 13 days following a non‐irradiated red cell transfusion. Results The patient had not previously received purine analogues and none of the donors was homozygous for a human leucocyte antigen (HLA) haplotype that was shared by the recipient. Therefore, his only apparent risk factor was lymphoplasmacytoid NHL. Conclusions This case further strengthens the argument that NHL per se is a risk factor for TA‐GvHD and supports the proposal that the guidelines for prophylactic irradiation of cellular blood products be extended to include all cases of NHL.