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A direct comparison of the antigen‐specific antibody profiles of intravenous immunoglobulins derived from US and UK donor plasma
Author(s) -
Matejtschuk P.,
Chidwick K.,
Prince A.,
More J. E.,
Goldblatt D.
Publication year - 2002
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1046/j.1423-0410.2002.00186.x
Subject(s) - antibody , immunoassay , immunology , medicine , antigen , human immunodeficiency virus (hiv) , intravenous immunoglobulins , virology
Background and Objectives Intravenous immunoglobulin (IVIG) is used in a range of immunodeficiency states that require a broad spectrum of protective antibodies to a range of common pathogens. A comparison of the antigen‐specific antibody profile of preparations of an IVIG (Vigam®) derived from US and UK sourced plasma was performed, and these preparations were also compared with three other IVIG products from different manufacturers. Materials and Methods Antibodies against a range of bacterial and viral pathogens were measured by immunoassay. Results Similar profiles were found for Vigam® made from UK and US source plasma and also for the other three IVIGs tested, but some specific differences were observed. Conclusions IVIG preparations have a similar therapeutic spectrum of antibodies when prepared from plasma sourced either from the UK or the US.