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Polychlorinated biphenyls and organochlorine pesticides are eliminated from therapeutic Factor VIII and immunoglobulin concentrates and reduced in albumin by plasma fractionation
Author(s) -
Covaci A.,
Laub R.,
Di Giambattista M.,
Branckaert T.,
Hougardy V.,
Schepens P.
Publication year - 2002
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1046/j.1423-0410.2002.00168.x
Subject(s) - fractionation , chemistry , organochlorine pesticide , pollutant , pesticide , environmental chemistry , chromatography , albumin , globulin , biochemistry , endocrinology , biology , organic chemistry , agronomy
Background and Objectives Persistent organochlorine pollutants, such as polychlorinated biphenyls (PCBs) and organochlorine pesticides, are found in the general population and tend to accumulate in blood and tissues. Their distribution was examined in the starting plasma pools for fractionation, Cohn plasma fractions and therapeutic concentrates. Materials and Methods In each process fraction, total protein, cholesterol and triglycerides were measured as well as organochlorine pesticides and PCB congeners. Results Organochlorine compounds were undetectable in cryoprecipitate, Cohn fraction I, Factor VIII and immunoglobulin concentrates, and reduced in albumin preparations. Conclusion Cohn plasma fractionation is very efficient for removing pollutants present in the starting material. Biological processing techniques should be analysed for their capacity to eliminate/reduce persistent organochlorine pollutants from the therapeutic proteins.