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Direct evidence for the existence of Miltenberger a antigen
Author(s) -
Chen V.,
Halverson G.,
Wasniowska K.,
Lisowska E.,
Chen J.,
Moulds M.,
Reid M. E.
Publication year - 2001
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1046/j.1423-0410.2001.00042.x
Subject(s) - antigen , polyclonal antibodies , epitope , phenotype , monoclonal antibody , isoantigens , monoclonal , microbiology and biotechnology , blood group antigens , immunology , medicine , antibody , biology , genetics , gene
The Miltenberger (Mi) subsystem, which originally consisted of four phenotypes, now has 11 phenotypes. The antigens of this subsystem belong to the MNS blood group system. The Mi a antigen has been reported to be present on red blood cells with several Miltenberger phenotypes, namely: Mi.I, Mi.II, Mi.III, Mi.IV, Mi.VI and Mi.X. However, the existence of the Mi a antigen as a separate entity has been in question and difficult to prove with polyclonal reagents. We report the first monoclonal anti‐Mi a (GAMA210), whose epitope is TNDKHKRD or QTNDMHKR, and thereby confirm the existence of the Mi a antigen.