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The Relationship between New Variant Creutzfeldt‐Jakob Disease and Bovine Spongiform Encephalopathy
Author(s) -
Knight Richard
Publication year - 1999
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1046/j.1423-0410.1999.7640203.x
Subject(s) - bovine spongiform encephalopathy , scrapie , virology , disease , transmissible spongiform encephalopathy , kuru , slow virus , encephalopathy , medicine , pathological , biology , prion protein , pathology , viral disease , virus
Creutzfeldt‐Jakob disease (CJD) has been transmitted in the laboratory and also by iatrogenic accident. However, research has failed to find evidence that its most common form (sporadic CJD) is a natural infection and, in particular, that there is a causal link with scrapie. Bovine spongiform encephalopathy (BSE) probably resulted from scrapie infection in cattle food. In the wake of the BSE epidemic, a novel clinico‐pathological form of CJD has been recognized: new variant CJD (nvCJD). This paper reviews the relationship between nvCJD and BSE and presents the accumulated evidence supporting the view that nvCJD resulted from BSE contamination of human food.