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Prevalence of GBV C/HGV RNA and GBV C/HGV Antibodies in French Volunteer Blood Donors: Results of a Collaborative Study
Author(s) -
Mercier B.,
Barclais A.,
Botte C.,
Cantalube J.F.,
Coste J.,
Defer C.,
Gautreau C.,
Giannoli C.,
Halfon P.,
Lepot I.,
Loiseau P.,
Martial J.,
Montcharmont P.,
Merel P.,
Ouzan D.,
Ravera N.,
Follana J.,
Césaire R.,
Janot C.,
Lemaire J.M.,
Micco P.,
Vezon G.,
Férec C.
Publication year - 1999
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1046/j.1423-0410.1999.7630166.x
Subject(s) - gb virus c , virology , medicine , serology , antibody , flaviviridae , hepatitis c virus , virus , incidence (geometry) , flavivirus , immunology , physics , optics
Background and Objectives:Posttransfusion hepatitis still occurs at an incidence of about 1 in 118,000 for HBV and 1 in 220,000 for HCV. This collaborative study aimed to determine the prevalence of a novel flavivirus, GBVC/HGV, even though its role in transfusion‐associated hepatitis is uncertain. Materials and Methods: GBVC/HGV RNA was detected by PCR using either the Boehringer detection kit or by primers previously described. HGV antibodies were detected by a serological assay from Boehringer. Results: The observed GBVC/HGV RNA frequency was 3.4%. HGV antibodies occurred in 9.5% of donors. Conclusion: In our study, 12.9% of the donors had been in contact with the GBVC/HGV virus.