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Neonatal Alloimmune Thrombocytopenia due to Anti‐HPA‐1b (PL A2 ) (Zw b )
Author(s) -
Winters J.L.,
Jennings C.D.,
Desai N.S.,
Dickson L.G.,
Ford R.F.
Publication year - 1998
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1046/j.1423-0410.1998.7440256.x
Subject(s) - neonatal alloimmune thrombocytopenia , antibody , medicine , platelet , pregnancy , immunology , platelet transfusion , isoantibodies , exchange transfusion , phenotype , antigen , human leukocyte antigen , pediatrics , fetus , biology , genetics , gene
Background : Neonatal alloimmune thrombocytopenia is a rare condition due to passively acquired maternal antibodies directed against paternal platelet antigens inherited by the infant. Only 5 cases have been reported due to antibodies against HPA‐lb (PL A2 ) (Zw b ). Case Report : We report a case of neonatal alloimmune thrombocytopenia due to anti‐HPA‐lb in the second pregnancy of a 26‐year‐old Caucasian female. The male infant was treated with a 5‐day course of intravenous immunoglobulin without complications. We report the HLA phenotype of the infant's mother and summarize the previous case reports due to anti‐HPA‐lb. Conclusion : Based on this case and a review of the literature, intravenous immunoglobulin as well as random donor exchange transfusion and random donor platelet transfusions are effective in the treatment of neonatal alloimmune thrombocytopenia due to anti‐HPA‐lb. Obvious associations between HLA alleles and sensitization to HPA‐lb have not been elucidated.