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Severe Neonatal Alloimmune Thrombocytopenia due to Anti‐HPA‐3a
Author(s) -
Boehlen F.,
Kaplan C.,
Moerloose P.
Publication year - 1998
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1046/j.1423-0410.1998.7430201.x
Subject(s) - neonatal alloimmune thrombocytopenia , genotyping , immunology , abo blood group system , serology , human leukocyte antigen , medicine , antibody , platelet , typing , antigen , isoantibodies , monoclonal antibody , pregnancy , genotype , biology , fetus , genetics , gene
Background and Objectives: Neonatal alloimmune thrombocytopenia is usually attributable to HPA‐la antibodies. We report a case of parental platelet antigen incompatibility associated with a severe neonatal thrombocytopenia secondary to alloimmunization to HPA‐3a. Materials and Methods: Platelet antibodies were detected by the monoclonal antibody‐specific immobilization of platelet antigens, genotyping of the platelets by PCR, and HLA typing by serologic procedures and PCR. Results: Genotyping of maternal and paternal platelets confirmed the incompatibility in the HPA‐3a system. It is noteworthy that the mother is of the HLA type DRB3*0101, is ABO‐incompatible with her husband, and also has HLA class I antibodies. Conclusion: Severe neonatal thrombocytopenia associated with HPA‐3a alloimmunization is infrequent and all the factors mentioned above could have played a role in the severity of the disease.