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Reactivation of Recipient Antibody to Blood Cell Antigens Soon After Allogeneic Bone Marrow Transplantation
Author(s) -
Wernet Dorothee,
Schnaidt Martina,
Northoff Hinnak
Publication year - 1996
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1046/j.1423-0410.1996.7140212.x
Subject(s) - antigen , antibody , immunology , transplantation , bone marrow , human leukocyte antigen , medicine , isoantibodies , bone marrow transplantation , biology
Reactivation of recipient antibody to HLA and red blood cell antigens is described in 8 patients after allogeneic bone marrow transplantation. These IgG antibodies can be detected between day 10 and day 40 after transplantation and, in 1 patient, can be shown to be antigen‐independent. We hypothesize that, induced by graft recognition of recipient antigens, antigen‐independent activation of sensitized recipient B cells takes place leading to transient antibody production.