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The effects of spontaneous mutation on competitive fitness in Drosophila melanogaster
Author(s) -
Ávila V.,
GarcíaDorado A.
Publication year - 2002
Publication title -
journal of evolutionary biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.289
H-Index - 128
eISSN - 1420-9101
pISSN - 1010-061X
DOI - 10.1046/j.1420-9101.2002.00421.x
Subject(s) - biology , drosophila melanogaster , genetics , mutation rate , chromosome , population , mutation accumulation , mutation , gamete , evolutionary biology , gene , demography , sperm , sociology
We have analysed the effect of 288 generations of mutation accumulation (MA) on chromosome II competitive fitness in 21 full‐sib lines of Drosophila melanogaster and in a large control population, all derived from the same isogenic base. The rate of mean log‐fitness decline and that of increase of the between‐line variance were consistent with a low rate ( λ ≈ 0.03 per gamete and generation), and moderate average fitness effect [ E ( s ) ≈ 0.1] of deleterious mutation. Subsequently, crosses were made between pairs of MA lines, and these were maintained with effective size on the order of a few tens. In these crosses, MA recombinant chromosomes quickly recovered to about the average fitness level of control chromosomes. Thus, deleterious mutations responsible for the fitness decline were efficiently selected against in relatively small populations, confirming that their effects were larger than a few percent.