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Isobutyl‐nitrite‐induced methemoglobinemia; treatment with an exchange blood transfusion during hyperbaric oxygenation
Author(s) -
Jansen T.,
Barnung S.,
Mortensen C. R.,
Jansen E. C.
Publication year - 2003
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1046/j.1399-6576.2003.00246.x
Subject(s) - medicine , methemoglobinemia , hyperbaric oxygenation , anesthesia , nitrite , exchange transfusion , hypoxia (environmental) , oxygenation , blood transfusion , methemoglobin , hemoglobin , hyperbaric oxygen , oxygen , surgery , ecology , chemistry , organic chemistry , nitrate , biology
A young man was accidentally intoxicated with isobutyl nitrite by a threefold lethal dose. Due to nitrites' ability to change hemoglobine into methemoglobine the patient showed signs of severe hypoxia, which could not be treated by conventional means. Therefore the patient was rapidly transferred to a hyperbaric chamber. The patient was treated with pure oxygen at 283 kPa under which a blood exchange transfusion was performed. The patient fully recovered.