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A review of antidepressant‐induced hypomania in major depression: suggestions for DSM‐V
Author(s) -
Chun Benjamin JDH,
Dunner David L
Publication year - 2004
Publication title -
bipolar disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.285
H-Index - 129
eISSN - 1399-5618
pISSN - 1398-5647
DOI - 10.1046/j.1399-5618.2003.00084.x
Subject(s) - hypomania , antidepressant , mania , bipolar disorder , depression (economics) , psychiatry , psychology , bipolar ii disorder , major depressive disorder , major depressive episode , medicine , clinical psychology , mood , anxiety , economics , macroeconomics
Objectives: To determine if the classification of ‘antidepressant‐induced hypomania’ in DSM‐IV is supported by available data. Methods: We reviewed the available scientific literature to examine the incidence of mania and hypomania in non‐bipolar patients who were treated with antidepressants. Results: Eighty‐nine per cent of studies of antidepressants in major depressive disorder patients reported no cases of treatment‐induced hypomania. No instances of treatment‐induced hypomania were reported in three large studies of patients with chronic forms of depression. Conclusions: The rate of antidepressant‐induced hypomania in major depressive disorder is within the rate of misdiagnosis of bipolar depression as unipolar. Depressed patients who experience antidepressant‐associated hypomania are truly bipolar.