Safety issues with cyclosporine

The tnore even absorption characteristics of the Neoral® fortnulatioti of cyclosporitie cotitribute to its itnproved safety profile when compared with Sandimtnune®. Excessive dose adjusttnents of cyclosporitie are reduced, stable absorption is offered, and variability in cyclosporine blood levels is avoided. Short-tertn use of Neoral, i.e. for treattnent up to i year, also enhances its overall safety. As discussed in other articles in this supplement, the potetirial for side-effects of Neoral may be reduced by careful patient selection and by proper dosing. The adverse effects that may be associated with appropriate dosing of Neoral are reviewed iti this article.