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Vitamin D‐dependent rickets Type II with alopecia: two case reports and review of the literature
Author(s) -
Vitale Patricia
Publication year - 2003
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1046/j.1365-4362.2003.01816.x
Subject(s) - rickets , medicine , vitamin d and neurology , scalp , vitamin d deficiency , vitamin , endocrinology , dermatology
Vitamin D‐dependent rickets Type II is a rare autosomal recessive disorder. It usually presents with rachitic changes not responsive to Vitamin D treatment with elevated circulating levels of 1,25‐Dihydroxyvitamin D 3 , thus differentiating it from Vitamin D‐dependent rickets Type I. Alopecia of the scalp or the body is seen in some families with Vitamin D‐dependent rickets Type II. This is usually associated with more severe resistance to Vitamin D. We report two Saudi brothers with this disease, and review the salient features of this disease with emphasis on the associated alopecia.