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HLA‐DQ3 is associated with idiopathic guttate hypomelanosis, whereas HLA‐DR8 is not, in a group of renal transplant patients
Author(s) -
Arrunategui Adriana,
Trujillo Rodolfo A.,
Marulanda Maria P.,
Sandoval Fabian,
Wagner Adriana,
Alzate Alberto,
Falabella Rafael
Publication year - 2002
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1046/j.1365-4362.2002.01630.x
Subject(s) - human leukocyte antigen , medicine , etiology , immunology , genetic predisposition , heredity , histocompatibility , hla a , antigen , genetics , biology , disease
Background The etiology of idiopathic guttate hypomelanosis (IGH) remains uncertain; however, solar exposure and heredity have been proposed as causative factors. Objective To explore the genetic predisposition to the development of IGH. Methods A comparative case–control study was performed at a dermatology department at a university hospital. Forty‐seven subjects (22 renal transplant patients and 25 controls) were enrolled. Clinical examination and human leukocyte antigen (HLA) determination were performed. Results In the group of subjects with HLA‐DQ3 (10/13, P = 0.025), there was a statistically significant ( P < 0.05) positive association for the presence of IGH; in the group of subjects with HLA‐DR8 (6/6, P = 0.023), there was a statistically significant negative association for the presence of IGH. Conclusions The presence of HLA‐DQ3 in patients with IGH suggests a genetic basis in a group of renal transplant subjects. HLA‐DR8 was found in patients without IGH, and it could play a role as a “protective factor” preventing subjects from developing IGH.